The BeAtMuSiC program evaluates the change in binding affinity between proteins (or protein chains) caused by single-site mutations in their sequence. The predictions are based on the structure of the protein-protein complex. BeAtMuSiC gives the possibility to perform either manually specified mutations, or a systematic scan of all possible mutations in a protein chain (or group of chains), or at the protein-protein interface.

• Press PLAY to submit a query to BeAtMuSiC.
• Press LISTEN to check on your results.
• Press LEARN for additional help and information.

Method & Webserver : Dehouck Y, Kwasigroch JM, Rooman M, Gilis D. BeAtMuSiC: Prediction of changes in protein-protein binding affinity on mutations. Nucleic Acids Research 41:W333-W339 (2013).
doi: 10.1093/nar/gkt450

Participation to the CAPRI experiment : Moretti R. et al. Community-wide evaluation of methods for predicting the effect of mutations on protein-protein interactions. Proteins (2013).
doi: 10.1002/prot.24356